Filmstarts.de schreibt:
Der Film soll in einer Gotham-City ähnlichen Stadt namens Darkhaven, die von der Unterwelt beherrscht wird, in der heutigen Zeit spielen. Neben menschlichen Verbrechern herrschen Monster wie Frankenstein, Dracula, Dr Jekyll/Mr. Hyde, der Invisible Man oder der Glöckner von Notre Dame.
Etwas ausführlicher wird comingsoon.net:
Set in a dystopic present where vigilant gargoyles and ferocious demons rage in a battle for ultimate power, Victor Frankenstein's creation Adam (Aaron Eckhart) finds himself caught in the middle as both sides race to discover the secret to his immortality. From the creators of the hit supernatural saga, "Underworld,"comes the action thriller "I, Frankenstein," written for the screen and directed by Stuart Beattie based on the graphic novel "I, Frankenstein" by Kevin Grievous, and brought to life by a cast that includes Aaron Eckhart, Bill Nighy, Yvonne Strahovski, Miranda Otto, Jai Courtney, Socratis Otto, Mahesh Jadu, Caitlin Stasey and Aden Young as Victor Frankenstein.